WebDec 15, 2024 · In brief, circHMGCS1 is highly expressed in PCa and is positively correlated with the degree of malignancy. Over-expression of circHMGCS1 is not only associated with the proliferation of PCa cells but also blocks SC-induced pro-apoptotic effects. As a verified sponge of circHMGCS1, miR-205–5p is down-regulated in PCa tumors, which negatively ... WebResults: HB patients with high circHMGCS1 expression have shorted overall survival. Knockdown of circHMGCS1 inhibits HB cells proliferation and induces apoptosis. CircHMGCS1 regulates IGF2 and IGF1R expression via sponging miR-503-5p, and affects the downstream PI3K-Akt signaling pathway to regulate HB cell proliferation and …
CircHMGCS1 Promotes Hepatoblastoma Cell Proliferation by …
WebSep 15, 2024 · CircHMGCS1–016 can be explored as a new potential biomarker and therapeutic target for PD1-resistant ICC patients and is a forceful contributor in ICC development and immune tolerance via miR-1236-3p/CD73 and GAL-8 axis. Background Accumulating evidence indicates that circRNAs may serve as essential regulators in the … WebMar 31, 2024 · In conclusion, our research revealed circHMGCS1/miR-581/AURKA, circHMGCS1/miR-892a/KIF5B, and circTMCO3/miR-577/RHOA regulatory axes, which could serve as novel biomarkers in the detection of HCC. Finally, bioinformatics analysis indicated that the interaction pairs of the circRNAs mentioned above might be involved in … generational gap meaning
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WebFigure S3. The relationship between circHMGCS1 and HMGCS1. (A) qRT-PCR assays were performed to detect the expression level of HMGCS1 in siRNA transfected HepG2 and HUH6 cells (one-way analysis of variance, Dunnett’s test). (B)qRT-PCR assays were performed to detect the expression level of HMGCS1 in miR-503-5p transfected HepG2 … WebXu YP, Dong ZN, Wang SW, et al. CircHMGCS1-016 reshapes immune environment by sponging miR-1236-3p to regulate CD73 and GAL-8 expression in intrahepatic cholangiocarcinoma. J Exp Clin Cancer Res. 2024; 40 (1):290. doi: 10.1186/s13046-021-02095-2 [PMC free article] [Google Scholar] WebApr 7, 2024 · In addition, circHMGCS1 could promote the proliferation of hepatoblastoma cells by regulating the IGF signaling pathway and glutaminolysis and circHMGCS1 might be a potential prognostic marker and therapeutic target for hepatoblastoma . generational goals