Cullin_2 domain-containing protein

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August undefined, 2024

WebApr 28, 2011 · Cullin proteins are molecular scaffolds that have crucial roles in the post-translational modification of cellular proteins involving ubiquitin. The mammalian cullin … WebSep 1, 2003 · Two classes of E3s have been identified: the HECT domain proteins and the RING domain E3s (Glickman and Ciechanover, 2002). Among the best studied RING E3s are the SCF ubiquitin ligases (Elledge and Harper, 1998). Canonical SCF complexes are composed of SKP1, cullin 1 (CUL1), and the RING protein HRT1/RBX1/ROC1 …

Phosphorylation regulates cullin-based ubiquitination in ... - PubMed

WebProtein knowledgebase. UniParc. Sequence archive. Help. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. UniRef. Sequence clusters. … WebMay 23, 2016 · Cullin-2 is a member of the Cullin family, and it serves as a scaffold protein for Elongin B and C, Rbx1 and various substrate recognition receptors to form E3 … earthlink internet service prices

Systematic analysis and nomenclature of mammalian F-box proteins

WebOct 21, 2013 · The tumor suppressor VHL (von Hippel–Lindau) protein is a substrate receptor for Ubiquitin Cullin Ring Ligase complexes (CRLs), containing a BC-box domain that associates to the adaptor Elongin B/C. VHL targets hypoxia-inducible factor 1α to proteasome-dependent degradation. Gam1 is an adenoviral protein, which also … WebCul2 and Cul5 are the most structurally related among the cullins and use elongins B and C as adaptors to engage a variable substrate recruitment protein. Among the most well-studied substrate recruitment proteins are … WebBy examining genes arising from intra- and interchromosomal duplications involving the ancestral chromosome 2 fusion site, followed by PCR of a fetal brain cDNA library, Fan … earthlink llc georgia

A BTB/POZ domain-containing protein negatively

CULLIN_2 domain-containing protein (chicken) - PubChem

WebNov 10, 2000 · F-box proteins contain a wide range of secondary motifs including zinc fingers, cyclin domains, leucine zippers, ring fingers, tetratricopeptide (TPR) repeats, and proline-rich regions. The diversity of … WebAug 5, 2024 · CULLIN_2 domain-containing protein;Cullin-3;Cullin_Nedd8 domain-containing protein GeneRIFs: Gene References Into Functions KEL-8 is a substrate … earthlink jobs atlanta gaWebCRLs are multisubunit complexes containing a cullin (CUL1-7) as scaffold protein, a RING domain protein Rbx1 or Rbx2, an adaptor protein, and a substrate recognition subunit … cthulhu political party

"WebNov 5, 2013 · Abstract The tumor suppressor VHL (von Hippel-Lindau) protein is a substrate receptor for Ubiquitin Cullin Ring Ligase complexes (CRLs), containing a BC-box domain that associates to the adaptor Elongin B/C. VHL targets hypoxia-inducible factor 1α to proteasome-dependent degradation. " - Cullin_2 domain-containing protein

Cullin_2 domain-containing protein

WebApr 5, 2024 · 无齿E3泛素蛋白连接酶同源物（denticleless E3 ubiquitin protein ligase homolog，DTL）作为E3泛素连接酶中重要的底物适配器，是促进细胞周期进程和基因组稳定性的中心调控因子。 ... [2]。Cullin-RING E3泛素连接酶（Cullin-RING E3 ligase，CRL）拥有庞大的家族，参与基因转录 ... WebJul 20, 2012 · One of seven cullin proteins serves as a scaffold protein for the assembly of the multisubunit ubiquitin ligase complex. Cullin binds the RING domain protein …

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Cullins are a family of hydrophobic scaffold proteins which provide support for ubiquitin ligases (E3). All eukaryotes appear to have cullins. They combine with RING proteins to form Cullin-RING ubiquitin ligases (CRLs) that are highly diverse and play a role in myriad cellular processes, most notably protein degradation by ubiquitination. WebUnlike CLH2, the expression of this protein is dependent on the presence of a functional COI1 protein ( PubMed: 11950974 ). Plants silencing CLH1 exhibit reduced size, and decreased levels of chlorophyll and chlorophyllide ( PubMed: 15598807 ).

WebCiliary Proteins Primary Cilium Proteome Database This database shows proteins identified in primary cilia of mouse IMCD3 cells, compiled from three different proteomic publications: 1. Biochemical isolation using calcium-shock. Ishikawa, H., Thompson, J., Yates III, J. R., & Marshall, W. F. (2012). Proteomic Analysis of Mammalian Primary Cilia. WebApr 16, 2024 · The BTB domain, also known as POZ (poxvirus and zinc finger) domain, is a protein-protein interaction motif in eukaryotes [ 12]. All eukaryotes have a large variety of proteins that contain a BTB/POZ domain.

WebOct 9, 2024 · 9-Oct-2024 Summary Contributes to ubiquitin-protein transferase activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process; protein polyubiquitination; and regulation of microtubule-based process. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2024]

WebThis protein also has a C-terminal domain containing suppressor of cytokine signaling (SOCS) box ubiquitin ligase recruitment motifs found in substrate receptor proteins of the Cullin-RING E3 ubiquitin ligases. We demonstrate specific PCMTD1 binding to the canonical methyltransferase cofactor S -adenosylmethionine (AdoMet).

WebAug 16, 2004 · S- [NEDD8-protein]-yl- [E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin]-L-lysine = [E2 NEDD8-conjugating enzyme]-L-cysteine + N6- [NEDD8-protein]-yl- [cullin]-L-lysine. 1 publication EC:2.3.2.32 ( UniProtKB ENZYME Rhea) Pathway Protein modification; protein ubiquitination. Features Showing features for binding site. Expand … cthulhupunk pdfWebProtein knowledgebase. UniParc. Sequence archive. Help. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. UniRef. Sequence clusters. … cthulhu powers and abilitiesWebMar 29, 2024 · Roles of Cullin-2 E3 Ubiquitin Ligase Complex in Cancer Twist1 bound the Cul2 promoter. direct evidence that both A3A and HPV16 E7 interact with CUL2, … earthlink llc customer serviceWebMar 21, 2024 · DCUN1D4 (Defective In Cullin Neddylation 1 Domain Containing 4) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Class I MHC mediated antigen processing and presentation . An important paralog of this gene is DCUN1D5. UniProtKB/Swiss-Prot Summary for DCUN1D4 Gene earthlink login emailWebProtein knowledgebase. UniParc. Sequence archive. Help. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. UniRef. Sequence clusters. Proteomes. Protein sets from fully sequenced genomes. Annotation systems. Systems used to automatically annotate proteins with high accuracy: UniRule (Expertly curated rules) cthulhu rba aio box 60wWebJan 15, 2024 · In the CRL complex, the cullin protein serves as an elongated scaffold, recruiting the RING-FINGER PROTEIN RING BOX PROTEIN 1 (RBX1) and E2 to its … earthlink isp reviewsWebHere we identify Skp2 as a component of an Skp1-cullin-F-box complex that is based on a Cul1-Ro52 RING finger B-box coiled-coil motif family protein catalytic core. Ro52-containing complexes display E3 ligase activity and promote the ubiquitination of Thr187-phosphorylated p27 in a RING-dependent manner in vitro. cthulhu political