WebJul 1, 2024 · Intra-patient step-up dosing regimens have been incorporated in clinical trials to reduce cytokine release, but the mechanism behind this phenomenon remains elusive. In this study, we pre-clinically explored the phenomenon and its mechanism by using ERY974. ... A mouse surrogate version of ERY974 (mERY974) was first administered at a low … WebNov 17, 2024 · Determination of starting dose of the T cell-redirecting bispecific antibody ERY974 targeting glypican-3 in first-in-human clinical trial. (PubMed, Sci Rep) - P1 "For the phase I clinical trial, we selected 3.0 ng/kg as a starting dose, which was lower than the first-in-human dose calculated from both the no observed adverse effect level and …
Daniel Weiss, MD, CPI - VP & Head of Early Clinical …
WebOct 4, 2024 · We developed ERY974, a whole humanized immunoglobulin G-structured TRAB harboring a common light chain, which bispecifically binds to GPC3 and CD3. … WebJul 1, 2024 · Background: ERY974 is a humanized IgG4 bispecific T cell-redirecting antibody (TRAB) currently in a Phase 1 clinical trial (NCT02748837) in patients with solid tumors … jim shelley chod rig
Engineering a bispecific antibody with a common light chain ...
WebOct 10, 2024 · ERY974 is a bispecific antibody that binds to both GPC3 on the cancer cell membrane and to CD3, a membrane protein expressed on T cells, a type of lymphocyte. ... Chugai began phase I clinical trial of ERY974 in patients with GPC3 positive solid tumors in the United States in August 2016 (NCT02748837). WebApr 1, 2024 · (A) aCD3 mAb, and OKT-3 (B) ERY974 and ERY974/aCD3 mAb, for which the X axis shows the concentration of ERY974. Fig. 4. Percentages of CD25+ or CD69+ cells in CD4+ T cells and CD8+ T cells. WebSep 7, 2024 · ERY974 monotherapy shows a minor antitumour effect on non-inflamed NCI-H446 xenografted tumours, as infiltration of ERY974-redirected T cells is limited to the tumour-stromal boundary. However, combination therapy improves efficacy by promoting T cell infiltration into the tumour centre, and increasing ERY974 distribution in the tumour. instant cash payday loans online