WebInformações do antígeno Acredita-se que o produto do gene do fator de transcrição de microftalmia (MITF), um fator de transcrição nuclear do tipo bHLH, cumpre um papel na regulação de genes codificadores de enzimas necessárias para megalogênese. Estas incluem, tirosinase, TRP-1 e TRP-2. Web31 jan. 2024 · MITF binds the CLEAR-box motif in a symmetric manner. (A) Representative titration curves of each fluorescein-labeled oligonucleotide M-box (red), E-box (yellow) …
Stem Cell Factor-Inducible MITF-M Expression in Therapeutics …
WebImportancia clínica. El factor de transcripción MITF está asociado con el síndrome de Tietz [3] y con el síndrome de Waardenburg tipo IIa. [4] Genes diana. La proteína MITF reconoce las secuencias E-box (5'-CANNTG-3') y M-box (5'-TCANNTG-3' ó 5'-CANNTGA-3') en las regiones promotoras de los genes diana (donde C = citosina; A = adenina; T = timina; G … Web13 jan. 2024 · The microphthalmia-associated transcription factor (MITF) is a critical regulator of melanocyte development and differentiation. It also plays an important role in melanoma where it has been described as a molecular rheostat that, depending on activity levels, allows reversible switching between different cellular states. plantronics device not recognized
MITF in melanoma: mechanisms behind its expression and activity
WebInvitrogen Anti-MiTF Recombinant Monoclonal (JF100-01), Catalog # MA5-32554. Tested in Western Blot (WB), Immunocytochemistry (ICC/IF) and Flow Cytometry (Flow) applications. This antibody reacts with Human, Mouse, Rat samples. Supplied as 100 µL purified antibody (1 mg/mL). WebMITFは 塩基性ヘリックスループヘリックス (bHLH)- ロイシンジッパー (LZ)型 転写因子 であり、 メラノサイト 、 破骨細胞 、 マスト細胞 など多くの細胞種で細胞系列特異的な経路の調節に関与している [5] 。 細胞系列特異的とは遺伝子または形質が特定の細胞種のみで発現することを意味する。 MITFはこれらの正常な前駆体細胞の生存と生理学的機能 … Web摘要: 小眼畸形相关转录因子 (MITF)是黑素合成过程中最重要的转录因子。. 介绍了MITF基因及其转录水平的调控;综述了MITF蛋白及其对黑素细胞作用和黑素合成的调控,其主要 … plantronics e100 manual