Webb10 dec. 2015 · Using flow cytometry to assess SM1WT1 melanoma-infiltrating leukocytes immediately post therapy, we found that PLX3397 reduced the recruitment of CD11b + … Webbment commencing on day 6), or SM1WT1-OVA (treatment com- mencing on day 12) melanomas, compared with anti-CTLA-4 or anti-RANKLalone(datanotshown).Thecombinationeffectofanti-
JCI - Host immunity contributes to the anti-melanoma activity of …
WebbsubcutaneousgrowthofB16F10,SM1WT1(theoriginalparental line of LWT1), and LTW1 was equivalent between WT and CD39KO mice (Supplementary Figure1(a–c)). Expression of CD39 and CD73 was similar on SM1WT1 compared with LWT1 melanomas (Supplementary Figure1(d)), and in the TILs of SM1WT1 tumors at day 8 (Supplementary … Webbing B16F10 (melanoma), SM1WT1 (melanoma), and MC38 (colon cancer) lines (Supplemental Figure 2A). CD112, which shares some of the same interacting receptors (e.g., DNAM-1 and TIGIT) with CD155 (6), was expressed at very low lev-els on B16F10 and SM1WT1 cells and was undetectable on MC38 cells (Supplemental Figure 2A). We … ban jump
Host immunity contributes to the anti-melanoma activity of BRAF ...
Webb12 sep. 2016 · SM1WT1 subcutaneous tumors were significantly reduced in size and mass in DKO mice in comparison with A2AR.KO, CD73.KO, and WT mice (Figures 1 A, 1B, and … WebbThis experiment is similar to two performed. (B) Anti-CD39 mAb suppresses MCA1956 tumor growth in a dose-dependent manner. Groups (n = 10/group) of WT mice were injected s.c. with MCA1956 (1 × 106) fibrosarcoma cells on day 0 and treated i.p. with cIg (200 μg) or anti-CD39 (200 μg, 100 μg) on days 10, 13, 16, and 19. Webb9 jan. 2024 · SM1WT1 generally does not respond to PD-1 blockade. When we collected end-stage SM1WT1 tumors for flow-cytometry analysis, we observed a significant … piston pin hone